I can't believe I paid ten-thousand dollars for this class. What the hell was that lab fee for!?

Otto

Marge everything is a sin. Have you ever sat down and read this thing? (holds up the bible) -Technically we're not allowed to go to the bathroom.

Reverend Lovejoy

Marge: We don't think you're slow. But on the other hand, it's not like you go to museums, or read books or anything.
Homer: You think I don't want to? It's those TV networks, Marge, they won't let me. One quality show after another, each one fresher ad more brilliant than the last. If they only stumbled once, just gave us thirty minutes to ourselves! But they won't! They won't let me live!

If he can teach a class, then he can teach a class! I mean, I can teach a class!

Homer

Homer: Oh. And how is education supposed to make me feel smarter? Besides, every time I learn something new, it pushes some old stuff out of my brain. Remember when I took that home wine-making course and I forgot how to drive?
Marge: That's because you were drunk!
Homer: And how.

Homer: Okay, brain. If we don't think of something, Marge will leave us forever!
Homer's Brain: Eat the pudding, eat the pudding, eat the pudding, eat the pudding, eat the pudding...
Homer: Well, alright. But then we gotta get to work. (starts eating the pudding)

Annex Manager: We need someone to teach a course on how to build a successful marriage.
Homer: I'll do it! Anything to get me out of that house, away from all that nagging, and noise... uh, of a family of love. Tra-la-la-la!

Annex Manager: Now Tell me Mr. Simpson, what special skills could you teach a class on?
Homer: Uh... I can tell the difference between butter and I Can't Believe It's Not Butter.
Annex Manager: No you can't! No one can!

Groundskeeper Willy: If I wanted to see a man eat an orange, I'd have taken the orange eating class.
(cut to orange eating class)
Moleman: The eating of a good orange is a lot like a successful marriage.
Grampa: Just eat the damn orange!

(After an insect falls out of his hair) You think you get them all, but you forget about the eggs.

Otto

Bart: I missed you so much that I couldn't concentrate in school and I got an "F."
Homer: This is dated two weeks ago.
Bart: Oh, sorry. Here's a fresh one.

Moe: Hey Homer, why don't you nibble her elbow...that always melts her butter, heh heh.
Marge: Get out! Everyone get out now!
Apu: Ooooh, she's got to have it!

The Simpsons Season 5 Quotes

Homer: (Wearing glasses) The sum of the square roots of any two sides of an isosceles triangle is equal to the square root of the remaining side!
Man: (From inside a bathroom stall.) That's a right triangle, you idiot!
Homer: D'oh!

Homer: Aw, twenty dollars? I wanted a peanut!
Homer's Brain: Twenty dollars can buy many peanuts.
Homer: Explain how!
Homer's Brain: Money can be exchanged for goods and services.