If there's one thing we know about the much-anticipated sixth season of Grey's Anatomy, which premieres this Thursday night at 9 p.m. EST, it's that changes abound.

The new promotional poster for the show that we just came across and posted below reinforces that theme, with the tagline "The Season That Changes Everything" ...

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.