The Chief of Surgery at Seattle Grace, Dr. Richard Webber, and the Head of Trauma, Dr. Owen Hunt, are both profoundly affected by the death of their colleague, Dr. George O'Malley, on the upcoming sixth season of ABC's Grey's Anatomy. How could they not be?

How will the doctors respond to the departure of George (who was played by the disaffected T.R. Knight)? The actors themselves shed some light on this subject, as well as what we can expect with respect to their characters' personal lives, starting this September.

Follow the links below for interviews with:

• Kevin McKidd
• James Pickens, Jr.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.