After the events of Dorian's ball, Vanessa seeks the safety of the Cut-Wife's cottage.
Though Ethan is there to protect her, he teaches her to shoot. The Nightcomers are well aware of the little cottage and will no doubt attack. From the looks of the clip, it's the cottage that will not survive this next encounter.
Mr. Lyle warns Victor that the relics mention the coming of the beast. Will Lucifer make himself known on Penny Dreadful Season 2 Episode 7?
Either way, Ms. Ives is once again in mortal danger.