Annalise Keating - How to Get Away With Murder
After Wes was killed in a house fire, Annalise was arrested at the scene and charged with his murder and arson, which reduced her home/office to ashes. You better believe she got her revenge the moment she was free again.
Nic - The Resident
Nic was framed by the show's biggest villain, Dr. Lane Hunter, for allegedly killing Lily Kendall. Hunter, who treated perfectly healthy patients for cancer as part of an insurance fraud scheme, killed Lily but made it seem like it was Nic's carelessness. In the end, Dr. Hunter got everything she deserved.
Olinksy - Chicago PD
Olinsky was a ride-or-die partner who took the fall for a murder that Voight committed. While Voight tried his best to clear Olinsky's name, the detective was attacked in prison and succumbed to his injuries in one of the saddest moments on the series.
Oliver Queen - Arrow
Oliver Queen confessed to being his vigilante alter ego, The Green Arrow, which landed him a sentence at Slabside Maximum Prison alongside all the bad guys he personally locked up there. Yeah, not an ideal situation.
Barry Allen - The Flash
DeVoe framed Barry for his murder by assuming Dominic's body, and planting his previous body in Barry and Iris' apartment stabbed with a knife that had Barry's fingerprints.
Callie - The Fosters
Callie was a trouble magnet and had multiple juvie stays on her record. Some of the biggest crimes included destruction of property and leaving the scene of a crime, which she quickly learned was a felony.