V (Orange is the New Black)
Orange is the New Black Season 2 introduced us to a new character who had a beef with Red. Through some flashbacks and a current scheme to start selling cigarettes and drugs in the prison, we got to see exactly how far V would go in the name of self-preservation. Which included taking advantage of Suzanne "Crazy Eyes" Warren's loyalty.
Oh, Jacob. What a manipulative enigma. Jacob is probably about as close to god as you can get on Lost. Jacob is revealed as the one who caused Oceanic Flight 815 to crash onto the island, and he has considerable influence over many of the main characters of the series.
Patty Hewes (Damages)
You'd think Patty Hewes would have a strong moral center as a lawyer, right? Wrong. This woman is skilled at playing the long game and making sure she wins, at any cost. She's so personable too, which probably makes it that much worse.
Scorpious is pretty good at getting what he wants. What wants is John Crichton's knowledge of wormholes, and every time he encounters the wayward traveler from Earth, he manipulates the situation so that he can almost get what he's searching for. Fortunately for Crichton, he never seems to get the information.
Rumplestiltskin (Once Upon a Time)
Rumplestiltskin may as well have a Ph.D. in dealmaking. He constantly responds to people in distress and asks for what seems to be innocuous favors in return. But, things are rarely as they appear and Rumple's prices are typically part of a much bigger plot.
Michael (The Good Place)
This demon invented a version of hell that looked like heaven to torture humans. Humans that he selected to be together because he knew that they would get on each other's nerves. That probably says it all, but then let's add on the fact that he sent them back to Earth to try to prove that people are good and can change, but then kept interfering to get his desired outcome. That's a master manipulator if I've ever seen one.