Anne Boleyn (The Tudors)
Perhaps the greatest femme fatale of all time, Anne Boleyn seduced her way into King Henry's bed and managed to get a crown in the process! We're not saying she poisoned his first wife or anything... but she definitely thought about it.
Annalise Keating (How To Get Away With Murder)
Annalise might be the person you call when you need to get away with murder, but she's also the person you call when you want to plan one, too. She's deadly smart, and more than a little cutthroat. Just ask Rebecca and Sam.
Cersei Lannister (Game of Thrones)
Is there anyone Cersei won't kill or seduce to get her way? She certainly seems to run circles around most of the men in King's Landing, even if those men happen to be related to her. Creepy twincest aside, Cersei is definitely Trouble with a capital T.
Bo Dennis (Lost Girl)
If we're talking deadly, then Bo has got to be part of the conversation. One kiss from this girl can knock you off your feet, and not in the romantic, ooey-goey way. More like in the stolen-life-force way. That's what you get when you mess with a succubus!
Pam Swynford de Beaufort (True Blood)
Pam Swynford de Beaufort – first off, what an awesome name – is another vampire that makes this list. She's got a thing for lesbian jokes and torture, and both seem to kind of turn her on. Either way, she seems like the type to bed and behead, if you know what we mean.
Lucrezia Borgia (The Borgias)
For the Pope's daughter, Lucrezia sure did love to sin. She did the dirty with her own brother for goodness' sake! She was delightfully wicked to watch on screen, and if she didn't murder you herself, she'd probably just have Cesare do it for her.