Alex & Meredith on Grey's Anatomy
Grey's Anatomy has been on for so long now, it's hard to remember a time when Alex and Meredith weren't the definition of best friend goals. But there was once a time when they weren't nearly as close, vying for coveted spots and annoying one another. One of the best things this show has done over the years is cultivate their relationship and make it one of the cornerstones of the later parts of the series.
Lucas & Nathan on One Tree Hill
The Scott brothers went through many ups and downs over the years and in the early days they allowed their rivalry to consume them. Eventually their brotherly bond won out and the two would continue to look out for one another throughout the series long run.
Jack & Ryan on Station 19
Jack and Ryan were destined to be rivals as they battled for Andy's heart and continously butted heads. But with neither involved with Andy anymore and a deeper respect forming, is it possible these two could become real friends? Time will tell!
Brooke & Haley on One Tree Hill
Brooke and Haley didn't start off friends, but they sure did end that way! It all started that night Brooke renamed Haley and the rest, as they say, is history!
Max & Helen on New Amsterdam
The first few meetings between the new Medical Director and the Head of Oncology were tense, to put it midly. Helen wasn't in the hospital nearly enough and Max just wasn't going to let that slide. However, an unexpected diagnosis has continued to bring them closer and closer and their relationship is slowly becoming one of the greatest aspects of the new medical drama.
Lemon & Zoe on Hart of Dixie
Remember when Lemon was engaged to George, but then they called the wedding off and George showed up in the pouring rain to tell Zoe how he felt about her? Yeah, that pretty much cemented these two would never be besties. They eventually did find some common ground throughout the show's run and eventually formed a really sweet friendship.