In the twenty first season premiere, written by Seth Rogen, Comic Book Guy's comic, Everyman, becomes popular and it's made into a movie. Homer is cast as the lead role, but struggles staying in shape for the role.
Chalmers: We have reason to believe your son has been dealing drugs. Marge: Dealing drugs? That's impossible, he doesn't have the math skills. Chalmers: Marge, I know you've tried everything to keep Bart under control. Ritalin, Lithium, Zoloft. Well they didn't work, he has moved on to drugs.