The Big Bang Theory Season 3 Episode 18
The Pants Alternative
When Sheldon wins an award and is forced to give an acceptance speech, he reveals to the gang he has stage freight. They form as his C-Men (X-Men for Cooper, of course). Leonard attempts to use psychology, Raj attempts to teach him meditation, Penny takes him suit shopping, and Wolowitz pretends to care.
In the end, Sheldon still gets nervous before giving his speech and Penny convinces him to drink to loosen up. After chugging wine, he goes up and gives a speech that results in him not wearing pants and on YouTube.