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Dean feels the effects of the First Blade and Metatron makes his move on humanity.
After a massive attack on the angels, Castiel calls Sam and Dean for help.
Cas caputures one of Metatron's angels and asks Sam and Dean for help interrogating him.
Sam and Dean investigate a case where a group of mafia-type monsters run the underbelly of Chicago.
Sheriff Mills returns to Supernatural when she requires assistance with a vampire nest.
Metatron is trying to play God on Supernatural. How will he be stopped?
Misha Collins makes his directorial debut in this episode when Dean feels the after effects of the mark of Cain.
Crowley is in need of an intervention when he becomes addited to human blood.
The Ghostfacers return when Sam and Dean investigate the death of a teenage girl whose final selfie revealed a ghostly image in the background.
Sam and Dean discover the Men of Letters bunker is haunted and their investigation leads them to a storage facility where they discover that demons have been hiding a very prized possession.