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Jackson and Lexie are getting more serious. Lexie tells Mark she is seeing someone else, and he figures out it is Jackson. Mark and Arizona fight over Callie’s baby shower, and Arizona is annoyed when it seems that Mark actually knows Callie better.
Adele has tested positive for early onset Alzheimer’s but is in denial. The Chief is desperate to get her into Derek’s trial. Adele is tested, barely passes the test, and finally realizes she is ill.
Bailey and Eli argue but end up making up and getting back together. The Chief performs an experimental procedure on a patient before the FDA approves it. The residents fight to get on the diabetes trial and to become chief resident.
April dumps Stark after everyone gives her a hard time for dating him.
Lucy ends up kissing Alex after hearing about his past from Meredith.
Henry is brought into the hospital and declares his feelings for Teddy. Cristina performs his necessary surgery, and then Teddy tells Henry she does not feel the same way about him.
The episode ends with Arizona and Callie getting into a car accident after Arizona proposes.