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This week's Family Guy, "Livin' On A Prayer," revolves around Stewie's new best friend who is diagnosed with cancer. When Lois and Peter take him to the hospital, they find out that the parents don't believe in medical treatment.
Quagmire's sister Brenda returns in "Screams of Silence: The Story of Brenda," as Quagmire, Joe, Bonnie and the Griffins decide to take matters into their own hands against her abusive boyfriend, Jeff.