After initially turning down a wealthy business man who thinks someone has given him a hereditary disease Sherlock and Watson take his case after a scientist who agree it was possible to give the disease was murdered.
Holmes: Why do you suppose you hate your job so much? Watson: I don't hate my job. Holmes: You have two alarm clocks. No one with two alarm clocks loves their job. Two alarm clocks mean it's a chore for you to get up in the morning.
Watson: How do you do it, guess things? Sherlock: I observe and then I deduce. Watson: How did you know I was a doctor, you said you could tell from my hands. Sherlock: Hand, singular. It was soft no calluses. Watson: How did you know my father had an affair? Sherlock: Google. Not everything is deducible.