Raj: When stuff like this gets me down, you know what I like to do?
Howard: Sing "Hakuna Matata" like an eight-year-old girl?
Raj: Wrong, smarty-pants. It's "Everything Is Awesome" from The Lego Movie.

Amy: Say, Betsy Ross, what you working on?
Sheldon as Betsy Ross: I have no idea. Because the story of me sewing the first American flag is unsupported poppycock.
Amy: Then who did sew it, hmm?
Sheldon as Betsy Ross: Don't ask me. I'm just a simple seamstress whose descendants are...out to make a quick buck!

Dan: Bernadette. Cute, sweet...vicious little Bernadette.
Penny: Come on. She's not that bad.
Dan: Oh, yeah? At the company picnic she yelled at me and my grandson for losing the three-legged race. I mean, he still calls her "that mean kid with the big boobies."

Raj: This old pen kind of proves gravity. When I tilt it, her bathing suit falls right off.
Howard: Oh, my dad used to have a pen like that. I dated it all through sixth grade.

You know, I thought cleaning out a dead professor's office was gonna just be boring, but then I found his dentures and realized it's also gross.

Raj

Sheldon: Now, I'm sure you're thinking, "The final episode? Who will stand between us and flag ignorance""
Amy: I know I was thinking that. Is this a show on flags or mind reading?
Sheldon: But the truth is I can no longer balance a full-time career, a popular Internet show, and a girlfriend.
Amy: And he really does have one, you jerks on the comment board. So as they say, all good things must come to an end.

I can't send it back. I had it engraved. "Here lie the ashes of Leonard Hofstadter. He thought he was right, but his roommate knew better."

Sheldon

Leonard: Okay, first of all, the surgery was a success, and secondly, I didn't even want you there.
Sheldon: Wow. I don't know which hurts worse-- my nose or my heart.

Penny: Okay, the reason he deceived you is you were being
a pain in the ass.
Sheldon: The reason I was being a pain in the B is because I was worried about him, and no one else was.
Penny: Really? You won't even say "A"?
Sheldon: You bet your sweet B I won't.

Sheldon: I assume this medical center's already treated the burns on your bottom from the recent pants fire.
Penny: 'Cause I'm a liar, liar?
Sheldon: That's for the fire marshal to determine.

Leonard: If there was an asteroid strike,wouldn't you die, too?
Sheldon: I don't know-- I'm smart and scrappy, I think I'd find a way.

Leonard: Buddy, I-I get that you're worried about me and I-I appreciate that, but I'm not going to die.
Sheldon: You don't know that.
Leonard: Well... I do know that it won't be from an asteroid strike.
Sheldon: You know who else said that? Every cocky T. Rex currently swimming around in the gas tank of your car.

TBBT Quotes

Mrs. Cooper: Shelly! I'm so glad you're here!
Sheldon: I saw you having naked sex.

Penny: Here's a question-- as an alien pretending to be human, are you planning to engage in any post-prom mating rituals with Amy?
Sheldon: There are post-prom mating rituals?
Penny: Not always. Unless your date drives a van with an air mattress, then always.
Sheldon: Well, if it's part of the prom experience, then I'm open to it.
Penny: You're kidding.
Sheldon: I may be an alien, but I have urges.If Amy wants to copulate by firing her eggs into space, well, then, I will happily catch them with the reproductive sac on my upper flermin. I'm not the best at reading facial cues, but I can see that you're a little turned on.