Penny: See, this is why I've been saying we should keep champagne on ice.
Sheldon: Sarcasm?
Amy: Yes.
Sheldon: That was tricky because when it comes to alcohol she generally means business.

Amy: After a careful evaluation of our relationship. We decided that the time was right to take a step forward.
Leonard: Okay.
Sheldon: Do you want to say it?
Amy: Let's say it together!
Sheldon and Amy: We're getting a turtle!

Excuse me. You better find my husband's mother, because one way or another, we're walking out of here with a dead woman!

Bernadette

Sheldon: If you could wake up tomorrow having gained any one quality or ability, what would it be?
Penny: Well, not to steal from the Bible, but turning water into wine sounds pretty good.

Leonard: I'm telling you, you can't create love in a few hours. Right?
Penny: Careful. You're poking at the whole foundation of The Bachelor.

Amy: I just read about an experiment designed to see if you can make two people fall in love in a matter of hours.
Leonard: That doesn't sound right. My research has shown that it takes three to five years of shameless begging.

Let's have a toast. To Mrs. Wolowitz. A loving mother ... to all of us. We'll miss you.

Leonard

Sheldon: I didn't care for her yelling, but now that I'm not going to hear it again, I'm sad.
Leonard: If you want, I can yell at you later.
Sheldon: It won't be as good.

Sheldon: When I lost my father, I didn't have any friends to help me through it. You do.
Penny: I really thought he was going to say, "Let it go."

No. My mom died.

Howard

Nathan Fillion: How about a guy who looks like Nathan Fillion, but a little more annoyed than Nathan Fillion usually is?
Leonard: What do you think?
Raj: Aww. That's good enough for Facebook.

Penny: I don't want five dollars. I want my dignity.
Amy: So what are we talking about? Ten bucks?

TBBT Quotes

Leonard: I'm not a crybaby.
Penny: Toy Story 3?
Leonard: They were holding hands in a furnace!

Two tea bags in one cup? You're not at a rave.

Sheldon