So what does the future hold for Sam and Dean? Well, uh, how do you feel about angels? Yeah. you know, because let me tell you, they're not nearly as lame as you think.

Chuck

Dean: Well, you sure look lovely tonight. Especially for a dead chick.
Latisha Actress: Buddy, I have heard that line 17 times tonight, okay? And all from dudes wearing MacGyver jackets. But you seem different.
Dean: How so?
Latisha Actress: Well, you don't seem scared of women.

Con Manager: Welcome to the first annual Supernatural convention. Uh, at 3:45 in the Magnolia Room we have the panel "Frightened Little Boy to Secret Life of Dean." And at 4:30, there's the "Homoerotic Subtext of Supernatural." And of course, the big hunt starts at 7 p.m. sharp.

You sorry sons of bitches. Why do you think you two are the vessels? Think about it. Michael, the big brother, loyal to an absent father. And Lucifer, the little brother, rebellious of daddy's plan. You two were born to this, boys! It's your destiny. It was always you. As it is in Heaven, so it must be on Earth. One brother has to kill the other.

Trickster

Dean: Ally with the Trickster?
Sam: Yeah.
Dean: A bloody, violent monster... and you wanna be Facebook friends with him? Nice, Sammy.

Dr. Piccolo: Doctor, seriously.
Sam: What?
Dr. Picolo: Seriously, you are brilliant, you know that, and a coward. You're a brilliant coward.
Sam: Uh, what are you talking about?
Dr. Picolo: As if you don't know.

Trickster/Gabriel: Where'd I screw up.
Sam: You didn't. Nobody gets the jump on Castiel like you did.
Dean: Mostly it was the way you talked about Armageddon.
Trickster/Gabriel: Meaning?
Dean: Well, call it personal experience. Nobody gets that angry unless they're talking about their own family.
Sam: So which one are you? Grumpy, Sleepy, or Douchy?

Trickster/Gabriel: Where'd you get the holy oil?
Dean: You might say we pulled it out of Sam's ass.

Sam: You've got to calm down.
Dean: Calm down? I am wearing sunglasses at night. You know who does that? No-talent douchebags. I hate this game. I hate that we're in a procedural cop show. And you want to know why. Because I hate procedural cop shows. It's like 300 of them on television, they're all the freakin' same.

I am doing all I can, to slightly lessen the spread of... of genital herpes. And that's a good thing.

Sam

Sam: It was you on the police scanner, right? This is a trick.
Trickster: Hello? Trickster.

Cathy Randolph: I could have sworn I saw... the Incredible Hulk.
Sam: The Incredible Hulk?
Cathy Randolph: I told you, it's crazy.
Dean: Bana or Norton?
Cathy Randolph: Oh, no, those movies were terrible. The TV Hulk.
Dean: Lou Ferrigno?
Cathy Randolph: Yes.

Supernatural Quotes

Boy, three bedrooms, two baths, and one homicide. This place is going to sell like hotcakes.

Dean

Dean: Do I know you?
Becky: No, but I know you.