PRESTON: "Actually, Chief..."
DEREK: "You can't be his best man!"
RICHARD: "Why not?"
DEREK: "It's unethical; it's a conflict of interest. The man wants to be Chief of Surgery."
PRESTON: "Actually, Derek..."
DEREK: "Not that that's why you're asking..."
PRESTON: "I was going to ask you."
DEREK: "Ask me what? [pauses] Oh! Really?"

RICHARD: "Tomorrow's a big day."
PRESTON: "And apart from the fact that Cristina hasn't written her vows, my best man just cancelled, and it's still raining."
DEREK: "He's not ready."
RICHARD: "You're never ready. I certainly wasn't. And then, the minute I saw Adele coming down that aisle... Well. Have you picked your best man?"

RICHARD: "So, how you feeling, Preston? You ready?"
PRESTON: "Well, I'm always ready for surgery."
DEREK: "I think he's talking about the wedding."

MEREDITH: "It looks like a teeny tiny catfish."
RICHARD: "Close. See there? Those are spines. This is a candirú fish."
CRISTINA: "The penis fish? This guy has the penis fish! In his... in his... Wow!"

MARK: "Why? I mean, did she tell you why?"
DEREK: "What did you do to her, Mark?"
RICHARD: "She didn’t give a reason."
MARK: "Did she tell you where she was going?"
RICHARD: "All she said was she needed some time. To be happy and free, if I recall correctly. Excuse me."

MARK: "Has anybody seen Addison?"
RICHARD: "Uh, she’s gone."
MARK: "Gone?"
RICHARD: "She took a leave of absence."

RICHARD: "Go away!"
ADDISON: "But we can help!"
PRESTON: [to Addison] "No, WE can help."
ADDISON: "What's that supposed to mean?"
PRESTON: "He doesn't have any woman parts."
ADDISON: "Irrelevant."

MARK: "'I’m a friendly guy?'"
RICHARD: "Sloan…"
MARK: "She pressed 5 and got off at 3. She’d rather walk up two flights of stairs than flirt with you. Hell, she’d rather climb up the outside of the building."
RICHARD: "I wasn’t flirting."
MARK: "You’re telling me!"

RICHARD: "Sloan. You brought me to a bar. You know I don’t drink."
MARK: "Which is perfect. Better to keep your mind sharp. Let the ladies do the drinking."

RICHARD: "Addison, I wouldn’t know where to start."
ADDISON: "Ask me to dance."
RICHARD: "Well, there’s no dance floor."
ADDISON: "So? Ask me anyway."

RICHARD: "Well, you think about it. I mean, when you’re married you like to think you still have game."
ADDISON: "Practice on me."
RICHARD: "I’m sorry?"
ADDISON: "Mark’s right. I mean, he’s wrong about so many things, but he is right about this. You need to get back out there. So, practice."

RICHARD: "The last time I tried to pick up a woman I had a Harvey Wallbanger in one hand and an afro pick in the other."
ADDISON: "Oh, Richard."

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Derek: I wanna be with you forever, and you wanna be with me forever. In order to do that we need to make vows. A commitment. A contract. Give me a piece of paper.
Meredith: I don't! I... I... I don't. I have post its!
Derek: (takes the post its and a pen) Ok. What do we wanna promise each other?
Meredith: That you'll love me... even when you hate me.
Derek: To love each other, even when we hate each other. (writes it down) No running. Ever! (Mer smiles and comes and sits in front of him) Nobody walks out. No matter what happens.
Meredith: No running.
Derek: (writes it down) What else?
Meredith: That we'll take care of each other, even when we're old, and smelly, and senile. And... if I get Alzheimer's and forget you...
Derek: I will remind you who I am, every day. To take care when old, senile, and smelly (writes it down) This is forever. (signs it) Sign.
Meredith: This is our wedding. A post it? (smiles)
Derek: Mhmmm. If you sign it.
Meredith: (signs it, and hands it back. Has tears in her eyes) Now what?
Derek: Now I kiss the bride. (They kiss)
Meredith: (smiling) Married.
Derek: (smiling) Married. (sticks their post it in Mer's locker) You see that? (Mer nods and smiles) Plenty of time.