PRESTON: "We have been through a lot this year."
DEREK: "And everybody else turned you down. Alright, what do I have to do?"
RICHARD: "Well, traditionally, the best man plans the bachelor party."
DEREK: "Drinks at Joe's after work."
PRESTON: "I knew you were the man for the job."

PRESTON: "Actually, Chief..."
DEREK: "You can't be his best man!"
RICHARD: "Why not?"
DEREK: "It's unethical; it's a conflict of interest. The man wants to be Chief of Surgery."
PRESTON: "Actually, Derek..."
DEREK: "Not that that's why you're asking..."
PRESTON: "I was going to ask you."
DEREK: "Ask me what? [pauses] Oh! Really?"

RICHARD: "Tomorrow's a big day."
PRESTON: "And apart from the fact that Cristina hasn't written her vows, my best man just cancelled, and it's still raining."
DEREK: "He's not ready."
RICHARD: "You're never ready. I certainly wasn't. And then, the minute I saw Adele coming down that aisle... Well. Have you picked your best man?"

RICHARD: "So, how you feeling, Preston? You ready?"
PRESTON: "Well, I'm always ready for surgery."
DEREK: "I think he's talking about the wedding."

MEREDITH: "It looks like a teeny tiny catfish."
RICHARD: "Close. See there? Those are spines. This is a candirú fish."
CRISTINA: "The penis fish? This guy has the penis fish! In his... in his... Wow!"

MARK: "Why? I mean, did she tell you why?"
DEREK: "What did you do to her, Mark?"
RICHARD: "She didn’t give a reason."
MARK: "Did she tell you where she was going?"
RICHARD: "All she said was she needed some time. To be happy and free, if I recall correctly. Excuse me."

MARK: "Has anybody seen Addison?"
RICHARD: "Uh, she’s gone."
MARK: "Gone?"
RICHARD: "She took a leave of absence."

RICHARD: "Go away!"
ADDISON: "But we can help!"
PRESTON: [to Addison] "No, WE can help."
ADDISON: "What's that supposed to mean?"
PRESTON: "He doesn't have any woman parts."
ADDISON: "Irrelevant."

MARK: "'I’m a friendly guy?'"
RICHARD: "Sloan…"
MARK: "She pressed 5 and got off at 3. She’d rather walk up two flights of stairs than flirt with you. Hell, she’d rather climb up the outside of the building."
RICHARD: "I wasn’t flirting."
MARK: "You’re telling me!"

RICHARD: "Sloan. You brought me to a bar. You know I don’t drink."
MARK: "Which is perfect. Better to keep your mind sharp. Let the ladies do the drinking."

RICHARD: "Addison, I wouldn’t know where to start."
ADDISON: "Ask me to dance."
RICHARD: "Well, there’s no dance floor."
ADDISON: "So? Ask me anyway."

RICHARD: "Well, you think about it. I mean, when you’re married you like to think you still have game."
ADDISON: "Practice on me."
RICHARD: "I’m sorry?"
ADDISON: "Mark’s right. I mean, he’s wrong about so many things, but he is right about this. You need to get back out there. So, practice."

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

I want to marry you. I want to have kids with you. I want to build us a house. I want to settle down and grow old with you. I want to die when I'm 110 years old, in your arms. I don't want 48 uninterrupted hours. I want a lifetime. Mmm. Do you see what happens? I say things like that and you fight the urge to run in the opposite direction. It's okay, I understand. I didn't, but now I do, I do. You're just getting started and I've been doing this for a long time now. Deep down, you're still an intern, and you're not ready.

Derek