Penny [at comic book store]: Everyone's staring at me!
Leonard: Don't worry, they're more scared of you than you are of them
Penny: Unlikely

Wolowitz: According to Alicia's Facebook page, she's hooking up with one of the producers on CSI.
Penny: Dead whore on TV, live one in real life.

Penny: It looks like the MySpace page of a 13 year old girl
Leonard: No it doesn't
Wolowitz: Oh please, Dateline could use it to attract predators

Sheldon: You'll effectively be paying yor self 5.19 per day
Penny: A day??
Sheldon: There are children in sneaker factories in Indonesia that outearn you

Sheldon: I'm a physicist. I have a working knowledge of the entire universe and everything it contains
Penny: Who's Radiohead?
Sheldon [after twitching for a minute]: I have a working knowledge of the important things

Wolowitz [about his phone call]: Looks like I'm going to have sex tonight
Penny: His right hand is calling him?

I'm from Nebraska. When we shoot things, it's because we want to eat em' or make them leave our boyfriends alone

Penny: What are we gonna do?
Leonard: We? No, no, no. You had your chance to be "we" for like a year and a half now. Right now, you are you and you are screwed.

Leonard [about his mother]: She's only been here a day and a half, and I'm seriously considering alcoholism as a new career path.
Penny: Hey, I talked to her for five minutes yesterday, and I've been half bombed ever since.

Penny: What was Leonard like when he was little?
Mrs. Hofstadter: Oh, I think you mean "young." He's always been little.

Penny [about his mom]: You can't let her get into your head
Leonard: It's too late for me, my head is her summer house

Leonard: What was the plan?
Penny: Um, waitress for six months and then become a movie star.
Leonard: Was there a Plan B?
Penny: TV star.

TBBT Quotes

Mrs. Cooper: Shelly! I'm so glad you're here!
Sheldon: I saw you having naked sex.

Penny: Here's a question-- as an alien pretending to be human, are you planning to engage in any post-prom mating rituals with Amy?
Sheldon: There are post-prom mating rituals?
Penny: Not always. Unless your date drives a van with an air mattress, then always.
Sheldon: Well, if it's part of the prom experience, then I'm open to it.
Penny: You're kidding.
Sheldon: I may be an alien, but I have urges.If Amy wants to copulate by firing her eggs into space, well, then, I will happily catch them with the reproductive sac on my upper flermin. I'm not the best at reading facial cues, but I can see that you're a little turned on.