Meredith is concerned about Amelia when Tom talks everyone through the seriousness of Amelia's brain tumor and his plan for surgery. She already lost one Shepherd to a brain issue, will she end up losing another?
DeLuca may be wondering what has brought his sister all the way from Italy to GSM because it can't possibly be just to visit her charming brother. Siblings always have ulterior motives. Will he be the person behind his sister making a startling new discovery?
Is Maggie part of the team of doctors helping Megan? It's always good to have a child prodigy on the case. What if she's working with DeLuca's sister instead? That could certainly make things interesting given her history with DeLuca.
How does DeLuca spend a day off? Coming into the hospital anyway. Maybe he wanted to check in on his sister who has mysteriously appeared at GSM with a controversial research trial that will get everyone talking.
Meredith and the others are busy coming up with a new plan to help Megan Hunt, but Amelia busies herself with a complicated new case. Could she be giving everyone the space they need, or is she avoiding Owen because a sibling rising from the dead stirs up feelings?
Things did not end well between Arizona and Eliza in the season finale. Their relationship came to an end just as Eliza's job at GSM came to an end. Either a significant amount of time has passed, or Arizona isn't that torn up about it. Could it have anything to do with her roommate's relative popping up?
Teddy is a familiar face to many, but there are new faces appearing in the premiere too. Who are all these new faces? Will there be any more old faces reappearing for nostalgia's sake? Tune in to find out!
Megan is with the best doctors in the country, so we're told, but that isn't enough to assuage Nathan's worry. He is impatiently waiting for more information on Megan's condition and a plan for what the others will do about it.
MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore." DEREK: "This thing with us is finished. It's over." MEREDITH: "Finally." DEREK: "Yeah, it's done." MEREDITH: "It is done."
Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."