In this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," an intense Dr. Derek Shepherd (Patrick Dempsey) appears to be getting more and more caught up in a really heated discussion with Dr. Owen Hunt (Kevin McKidd).
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In this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Dr. Derek Shepherd (Patrick Dempsey) appears to be in a heated debate with Dr. Owen Hunt (Kevin McKidd).
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In this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," guest star Bernadette Peters is sandwiched between ex-spouses George (TR Knight) and Callie (Sara Ramirez).
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In this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Callie tends to a patient who appears to be making a phone call. We're not experts but that's gotta be against some kind of policy. No?
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We've missed her. In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Meredith wears her familiar, concerned expression. We hope it's not for the worst ...
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In this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," it looks like one of our favorite docs is the one being consoled, not a patient, as is usually the case.
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In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," George tends to a patient (guest star Bernadette Peters). This is always one of O'Malley's strong suits.
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In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," a major accident leads to many medical traumas and personal dramas inside the halls of Seattle Grace. Will everyone be okay? We hope ...
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To say the least. In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," a major trauma has all the surgeons scrambling.
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Is it just us or is Callie looking pretty damn sexy lately? Hopefully her character gets more romantic storylines in Season 5 ... with either gender being fine by us!
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You have to admit, that would be an awesome couple name if they ever got together. And given the way this show has been headed in the past couple of seasons, we wouldn't put it past them.
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Meredith's arms are crossed. And our fingers are crossed that she and Derek will still be together after the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me."
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Grey's Anatomy Season 5 Episode 1 Quotes

[narrating] We all remember the bed time stories of our childhood. The shoe fit Cinderella, the frog was turned into a prince, sleeping beauty was awakened with a kiss. Once upon a time and then they lived happily ever after. Fairy tales. The stuff of dreams. the problem is, fairy tales don't come true. It's the other stories. The ones that start in dark and stormy nights and end in the unspeakable. The nightmares always seem to become the reality.

Meredith

Meredith: What happened!?
Cristina: A bus in front of him hit a telephone pole. He tried to swerve and miss it, but ...
Meredith: How bad is it?
Richard: Meredith -
Cristina: Meredith, you're gonna have to be strong.

Grey's Anatomy Season 5 Episode 1 Music

  Song Artist
Song Youthless Beck
Song Wins Jade McNelis
Song Jungle Drum Grey's Anatomy Emiliana Torrini