Patrick Smiles
Patrick Dempsey, who plays Derek Shepherd, smiles in a recent interview with Entertainment Tonight. He expressed great concern over the impending Hollywood writers' strike.

Rating: 4.8 / 5.0 (25 Votes)
Mrsmcsteamy

McDreamy!

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As I said before, there is no other.

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i love his smile!!!

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aaaaaah i just wanna squeeze his cheeks!!!

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Grey's Season 6 Cast Promo Pics
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Grey's Anatomy Quotes

Just because we can live without something, it doesn't mean we have to.

Meredith

Derek: I am calling post-it, Zola, Bailey, the tumors on the wall, ferryboat scrub caps. I thought D.C. was everything. I was wrong. You... you're everything. I love you and I'm not going to stop loving you. I can't live without you. I don't want to live without you, and I'm going to do everything in my power to prove it.
Meredith: I can live without you, but I don't want to. I don't ever want to.