Patrick Smiles
Patrick Dempsey, who plays Derek Shepherd, smiles in a recent interview with Entertainment Tonight. He expressed great concern over the impending Hollywood writers' strike.

Rating: 4.8 / 5.0 (25 Votes)
Mrsmcsteamy

McDreamy!

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As I said before, there is no other.

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i love his smile!!!

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aaaaaah i just wanna squeeze his cheeks!!!

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Grey's Season 6 Cast Promo Pics
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Grey's Anatomy Quotes

The first time I kissed my wife, she wasn't my wife then, she was just this girl in a bar. But when we kissed, it was like, I gotta tell you, it was like I'd never kissed any other woman before. It was like my first kiss. The right kiss.

Derek

[narrating] "At some point, you have to make a decision. Boundaries don't keep other people out, they fence you in. Life is messy, that's how we're made. So you can waste your life drawing lines or you can live your life crossing them. But there are some lines that are way too dangerous to cross. Here's what I know. If you're willing to throw caution to the wind and take a chance, the view from the other side... is spectacular."

MEREDITH