Mark and Derek Smile

Mark and Derek Smile

Attendings Mark and Derek smile in a promotional photo from "Life During Wartime," shot for the fifth season of Grey's Anatomy.
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Life During Wartime

Life During Wartime

It's a new day at Seattle Grace and a new doctor - Owen Hunt - is already shaking things up.
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Mark and Derek Look On

Mark and Derek Look On

In this picture from "Here Comes the Flood," from the fifth season of Grey's Anatomy, Mark and Derek listen as Richard addresses the staff.
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Mark Sloan, Erica Hahn

Mark Sloan, Erica Hahn

In a photo from "Here Comes the Flood," Mark Sloan and Erica Hahn share a conversation while the Chief talks. What could it be about?
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Callie Torres, Mark Sloan

Callie Torres, Mark Sloan

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Callie and Mark have a conversation outside Seattle Grace. Will they get together?
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Mark Sloan and Callie Torres

Mark Sloan and Callie Torres

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Callie and Mark have a conversation outside Seattle Grace. What's to come of their relationship, if anything?
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Torres and Sloan

Torres and Sloan

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Callie and Mark have a conversation outside Seattle Grace. What's to come of them?
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Mark and Callie

Mark and Callie

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Callie and Mark share a moment outside the hospital. What's to come of these two?
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Richard, Derek and Mark

Richard, Derek and Mark

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Derek, Mark and Richard are seen in a rare scene outside Seattle Grace. Where is it?
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Mark Sloan and Izzie Steves

Mark Sloan and Izzie Steves

In a still shot from "Losing My Mind," from the fourth season of Grey's Anatomy, Izzie and Mark have a serious conversation in the halls of Seattle Grace.
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Isobel and Mark

Isobel and Mark

In a still shot from "Losing My Mind," from the fourth season of Grey's Anatomy, Mark and Izzie have a serious conversation at Seattle Grace.
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Bizarre Love Triangle?

Bizarre Love Triangle?

Maybe, and not quite the way you think! Callie Torres, Erica Hahn and Mark Sloan have a conversation in "The Becoming."
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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith