Lois has a mid-life crisis triggered by her latest birthday on Family Guy. "Lois Comes Out of Her Shell" is the sixth episode of the show's 11th season.
Aunt Margarite [on her video will]: Lois, you were always my favorite niece; I just knew you would find a wonderful man who would make all your dreams come true. But I was wrong. Peter: And now you're dead. Score one for Peter