Izzie has a new group of interns following her around. We will have to see how Dr. Stevens adjusts to being the one bossing peeps around instead of in the doghouse.
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Izzie and Alex used to be an item, but now they're just good friends. It's nice to see for fans of both characters.
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Rumor has it that Miranda Bailey is a little bit bitter and back to her bad-ass self in Season Four. Izzie Stevens could attest to this.
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The Season Four cast of Grey's Anatomy: Starring the lovely Ellen Pompeo (Meredith Grey), Patrick Dempsey (Derek Shepherd), Sandra Oh (Cristina Yang), Katherine Heigl (Izzie Stevens), T.R. Knight (George O’Malley), Justin Chambers (Alex Karev), Chandra Wilson (Miranda Bailey), James Pickens, Jr. (Richard Webber), Sara Ramirez (Callie Torres), Eric Dane (Mark Sloan) and Chyler Leigh (Lexie Grey).
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Izzie Stevens (Katherine Heigl) has a cow on the set of Grey's Anatomy. Almost literally. Looking on are a bunch of younger people we believe are her (!) new interns!
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Katherine Heigl, a.k.a. Izzie Stevens, is modeling her own line of scrubs! Who would have guessed?
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George couldn't even muster any words after what Izzie said to him.
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Izzie professes her feelings for George.
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Will that be enough on Cristina's wedding day?
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Alex, Cristina, Izzie and George worry about Meredith.
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Izzie loves George so much it hurts.
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Our favorite group of interns chats it up.
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Grey's Anatomy Quotes

Meredith: You're me.
Amelia: What?
Meredith: You're me before Derek. I can be here for you. I can do this. I get you. I can be a twisted sister for you. Just tell me how do you want to play this?

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)