Izzie and George in "What a Difference a Day Makes," from the fifth season of Grey's Anatomy. The emotional wedding scene was one for all time.
Izzie stumbled on her way down the aisle, but George stepped in and helped his old friend make it to the steps, where she exchanged vows with Alex. Tear.
It was a sweet scene when George gave away Izzie to Alex at the wedding, when she became weak and could not walk under her own power. Tears were shed at this website.
George and Owen at the wedding of Alex and Izzie. These two make a great trauma surgeon team, as we've seen in recent weeks.
Alex and George look upward as a patient prepares to take the plunge ... and not the kind you want to see them take.
Meredith and George (he lives!) in a promotional photo from "Elevator Love Letter."
Meredith, Cristina and George in a photo from "Elevator Love Letter."
Remember Gizzie? As in George and Izzie? You can be forgiven if you don't, but here they are in a cute, recent photo.
George sighting! George sighting! Will O'Malley actually have a central role in this episode? Here's hoping.
A picture of Lexie and George, talking things out. Do we think she still wants him after she blew up at him the last time? We'll see...
Well, not that kind of action. But there's a lot of activity in this photo from "There's No 'I' in Team," from Season Five of Grey's Anatomy, as the residents discuss their respective days.
George O'Malley is now a resident at long last! How will he respond now that he has interns? Here's our guy in this photo from "There's No 'I' in Team," from Season Five of Grey's Anatomy.

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Lexie: [narrating] Grief may be a thing we all have in common, but it looks different on everyone.
Mark: It isn't just death we have to grieve. It's life. It's loss. It's change.
Alex: And when we wonder why it has to suck so much sometimes, has to hurt so bad. The thing we gotta try to remember is that it can turn on a dime.
Izzie: That's how you stay alive. When it hurts so much you can't breathe, that's how you survive.
Derek: By remembering that one day, somehow, impossibly, you won't feel this way. It won't hurt this much.
Bailey: Grief comes in its own time for everyone, in its own way.
Owen: So the best we can do, the best anyone can do, is try for honesty.
Meredith: The really crappy thing, the very worst part of grief is that you can't control it.
Arizona: The best we can do is try to let ourselves feel it when it comes.
Callie: And let it go when we can.
Meredith: The very worst part is that the minute you think you're past it, it starts all over again.
Cristina: And always, every time, it takes your breath away.
Meredith: There are five stages of grief. They look different on all of us, but there are always five.
Alex: Denial.
Derek: Anger.
Bailey: Bargaining.
Lexie: Depression.
Richard: Acceptance.