Callie, Derek and Meredith strategize in a photo from "Run, Baby, Run," the December 13, 2012 episode of Grey's Anatomy.
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Neve Campbell as Derek's sister in a photo from the December 6, 2012 episode of Grey's Anatomy, "Love Turns You Upside Down."
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Meredith and Derek in a photo from the December 6, 2012 episode of Grey's Anatomy, "Love Turns You Upside Down."
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Meredith and Derek with a sense of urgency in a photo from the December 6, 2012 episode of Grey's Anatomy, "Love Turns You Upside Down."
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Derek with Callie in the sixth episode of Grey's Anatomy Season 10, "Second Opinion."
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Callie with Derek in the sixth episode of Grey's Anatomy Season 10, "Second Opinion."
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Patrick Dempsey as Derek Shepherd on Grey's Anatomy, in his new role as an instructor. How do you think he will transition to this new role?
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Patrick Dempsey as Derek Shepherd on Grey's Anatomy, in his new role as an instructor. How do you think he'll handle it?
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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith