Owen and Derek in a scene from the February 14, 2013 episode of Grey's Anatomy, "Hard Bargain."
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Derek in a photo from "The End is the Beginning is the End," the January 17, 2013 episode of Grey's Anatomy.
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Derek smiles in a photo from "The End is the Beginning is the End," the January 17, 2013 episode of Grey's Anatomy.
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Does he ever!
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Dr. Derek Shepherd in his office in a photo from "Run, Baby, Run," the December 13, 2012 episode of Grey's Anatomy.
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Derek in his office in a photo from "Run, Baby, Run," the December 13, 2012 episode of Grey's Anatomy.
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Meredith and Derek in a photo from "Run, Baby, Run," the December 13, 2012 episode of Grey's Anatomy.
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Meredith and Derek look on in a photo from "Run, Baby, Run," the December 13, 2012 episode of Grey's Anatomy.
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Grey's Anatomy Quotes

When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.

Meredith

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)