The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.
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Whatever's going on, Derek looks very serious on Grey's Anatomy.
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When someone falls to the floor, Derek and Owen fight to save a life in "Do You Know?"
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It's like Derek is smiling into our soul in this Grey's Anatomy image, isn't it?
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Unfortunately for McDreamy, Meredith may be the one person who isn't awed by his big news in "Take It Back"
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Everyone wants Derek, even the President of the United States is giving him a call on Grey's Anatomy.
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Derek gets an offer that could change everything on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.
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Derek had to bring the baby in to work on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.
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Grey's Anatomy Quotes

Amelia: I think I'm falling in love with Owen Hunt, and I'm really afraid that it's gonna destroy me.
Derek: It wouldn't be love if it didn't.

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)