Callie and Arizona certainly qualify as that. Whether you believe they are really lesbians or not, the acting by Jessica Capshaw and Sara Ramirez is terrific.
Added:
Calliope Torres has been disowned by her family, but she loves Arizona, and she loves her work. We think this talented doctor will be okay.
Added:
Arizona and Callie are one of Grey's Anatomy's newest and most controversial couples. They're doing better lately, although there is always a crisis around the corner.
Added:
Callie and Arizona (Calzona) at the wedding of Alex and Izzie. Having gotten over their nonsensical fight over Callie's money problems, the two are back on good terms.
Added:
Callie and Arizona share a kiss in the church where the wedding took place. The people getting married where not who we thought, but the magic of the day was still palpable.
Added:
Callie introduces Arizona to her dad. That's not gonna go well, we have a hunch.
Added:
Callie (Sara Ramirez) and her father (Hector Elizondo) in "Sweet Surrender" from Season Five of Grey's Anatomy.
Added:
Callie Torres (Sara Ramirez) is a terrific Grey's Anatomy character, even if the writers can't decide what to do with her sexual orientation.
Added:

Grey's Anatomy Quotes

When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.

Meredith

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)