Lisa Marie Simpson, voiced by Yeardley Smith, is Homer and Marge's oldest duaghter and the middle child on The Simpsons.  Lisa is very intelligent, plays the saxophone, is a vegetarian, Buddhist, and definitely a bit of a young political activist.  She's basically the complete opposite of her brother, Bart.

Lisa Simpson Quotes

Nevada makes my butt look big.

Lisa

Ooh, an institute!

Lisa
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The Simpsons Quotes

You know, you remind me of a poem I can't remember, and a song that may never have existed, and a place I'm not sure I've ever been to.

Grampa

Mr. Burns: Oh, and one more thing: you must find the jade monkey before the next full moon.
Smithers Actually sir, we found the jade monkey. It was in your glove compartment.
Mr. Burns: And the road maps, and ice scraper?
Smithers: They were in there too, sir.
Mr. Burns: Excellent! It's all falling into place...