A statuesque blonde, Isobel "Izzie" Stevens put herself through medical school by modeling. Underwear. Wow.

When this fact is publicized by Dr. Alex Karev, who pinned pictures of her up in the locker room, Izzie flew off the handle. She later warmed up to Alex, however, and dated him briefly before catching him sleeping with a nurse and breaking it off. They remain friends, though.

At first, Izzie butted heads with Meredith over the latter's relationship with Dr. Shepherd. Izzie initially believed it was a plot for Dr. Grey to get ahead of her fellow interns, but the two have become good friends. They live in the same house, one that was also inhabited by George until the most recent episode.

When meeting a pregnant teenage girl from her hometown (outside Seattle), Izzie revealed that she, too, had a daughter at 16. Her daughter, who is now 12, was adopted and now lives in Santa Barbara, Calif. She made an appearance in Season Three, needing a bone marrow transplant from Izzie to stay alive. They did not communicate, however, as the girl's parents handled everything.

Izzie first showed an interest in surgery involving infants and young children, the specialty of Dr. Addison Shepherd. But she was deemed too emotional, a fact driven home when she fell in love with everyone's favorite heart patient, Denny Duquette. In her illegal attempt to get him a transplant, Izzie risked her entire medical career. While her efforts were successful, Denny died, and her career nearly followed suit.

Stevens eventually recovered from her loss, however, and after a probationary period, regained form as a surgeon, especially during a big ferry disaster. Denny also left her $8 million, which she used to open a free clinic at Seattle Grace. Unlucky in love, she became convinced she loves George as Season Three drew to a close. They hooked up one evening when drunk. How will this play out?

Stay tuned.

Izzie Stevens Quotes

Lexie: [narrating] Grief may be a thing we all have in common, but it looks different on everyone.
Mark: It isn't just death we have to grieve. It's life. It's loss. It's change.
Alex: And when we wonder why it has to suck so much sometimes, has to hurt so bad. The thing we gotta try to remember is that it can turn on a dime.
Izzie: That's how you stay alive. When it hurts so much you can't breathe, that's how you survive.
Derek: By remembering that one day, somehow, impossibly, you won't feel this way. It won't hurt this much.
Bailey: Grief comes in its own time for everyone, in its own way.
Owen: So the best we can do, the best anyone can do, is try for honesty.
Meredith: The really crappy thing, the very worst part of grief is that you can't control it.
Arizona: The best we can do is try to let ourselves feel it when it comes.
Callie: And let it go when we can.
Meredith: The very worst part is that the minute you think you're past it, it starts all over again.
Cristina: And always, every time, it takes your breath away.
Meredith: There are five stages of grief. They look different on all of us, but there are always five.
Alex: Denial.
Derek: Anger.
Bailey: Bargaining.
Lexie: Depression.
Richard: Acceptance.

IZZIE: "I'm a pretty girl."
RICHARD: "What?"
IZZIE: "I'm not being arrogant, it's just, it's just kind of a fact. For a long time I made a career from my looks, so I get it, I'm a pretty girl. And not in a 'from a certain angle' way, in an obvious way. It’s the blonde thing and the big boobs thing. Big boobs are a key to 'obvious pretty' if you know what I'm saying."
RICHARD: "Dr. Stevens-"
IZZIE: "It's how men see me. I'm not a smart girl or an interesting girl, I'm a pretty girl. The blonde and the boobs, it confuses guys into thinking I'm someone else. And I'm used to it. And I'm used to them walking away when they realize… But then Denny goes and asks me to marry him."
RICHARD: "Is that why you cut the wires?"
IZZIE: "He doesn't make me feel like I'm a pretty girl. He makes me feel like… like me. I think he might know me. And so, if I did cut the LVAT wire, and I'm not saying that I did, but if I did, then no. I don't feel guilty. I know that I should. I would if it were anybody else's. But I can't feel anything but happy."

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Burke was- He took something from me. He took little pieces of me, little pieces over time, so small I didn't even notice, you know? He wanted me to be something I wasn't, and I made myself into what he wanted. One day I was me Cristina Yang, and then suddenly I was lying for him, and jeopardizing my career, and agreeing to be married and wearing a ring, and being a bride. Until I was standing there in a wedding dress with no eyebrows, and I wasn't Cristina Yang anymore. And even then, I would've married him. I would have. I lost myself for a long time. And now that I'm finally me again, I can't. I love you. I love you more than I loved Burke. I love you. And that scares the crap out of me because when you asked me to ignore Teddy's page, you took a piece of me, and I let you. And that will never happen again.