Simon Helberg stars as Howard Wolowitz, the only one of the nerds that is not a doctor.  He is an engineer at Caltech and is friends with Leonard and Sheldon and frequently is over at their apartment.  Wolowitz mostly goes by his last name and still lives with his mother.

Most jokes with Wolowitz revolve around his failed attempts at womanizing, though he was given a girlfriend, Bernadette, in season three.

Howard Wolowitz Quotes

[Raj whispers in Wolowitz's ear]
Penny: What did he say?
Wolowitz: He compared Sheldon to a disposable feminine cleansing product one might use on a summer's eve.
Penny: Yeah, and the bag it came in

Raj: I know. Being an astrophysicist right now is like being a rock star.
Howard: Only without the sex.
Raj: Yeah, literally, none of it.

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TBBT Quotes

If I could speak the language of rabbits, they would be amazed and I would be their king... I would be kind to my rabbit subjects... at first.... One day, I hold a great ball for the President of France, but the rabbits don't come. I'm embarrassed so I eat all the lettuce in the world.. and make the rabbits watch.

Raj

Penny: I give up, he's impossible
Sheldon: I can't be impossible, I exist. I believe what you meant to say is, "I give up, he's improbable."