Homer Simpson, voiced by Dan Castellaneta, is the patriarch of The Simpsons and is definitely the main character.  Homer is an overweight, slob and a terrible father, but genuinely tries hard.

Homer previously had a job as safety inspector at Mr. Burns' Nuclear Power Plant, but good luck finding out what he's been doing for a living the last few years.

Homer Simpson Quotes

Oh, I have 3 kids and no money. Why can't I have no kids and 3 money!?

Homer

Homer: Alright brain. You don't like me and I don't like you. But let's just do this and I can get back to killing you with beer
Homer's Brain: It's a deal.

The Simpsons Quotes

Oh, I have 3 kids and no money. Why can't I have no kids and 3 money!?

Homer

Dearest Edna, I must leave you. Why, I cannot say. Where, you cannot know. How I will get there, I haven't decided yet. But one thing I can tell you, any time I hear the wind blow it will whisper the name Edna. And so let us part with a love that will echo through the ages. ---Woodrow

"Woodrow"