Homer Simpson, voiced by Dan Castellaneta, is the patriarch of The Simpsons and is definitely the main character.  Homer is an overweight, slob and a terrible father, but genuinely tries hard.

Homer previously had a job as safety inspector at Mr. Burns' Nuclear Power Plant, but good luck finding out what he's been doing for a living the last few years.

Homer Simpson Quotes

Homer: You know, one day honest citizens are going to stand up to you crooked cops.
Chief Wiggum: They are!? Oh no! Ha-have they set a date?

Homer: (Wearing glasses) The sum of the square roots of any two sides of an isosceles triangle is equal to the square root of the remaining side!
Man: (From inside a bathroom stall.) That's a right triangle, you idiot!
Homer: D'oh!

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The Simpsons Quotes

(The family watches Homer's launch on TV.)
Bart: Go, Dad, go!
Lisa: How doth the hero, strong and brave, a celestial path to the heavens paved!
(The family stares at her.)
Lisa: Go, Dad, go.

Homer: You know, one day honest citizens are going to stand up to you crooked cops.
Chief Wiggum: They are!? Oh no! Ha-have they set a date?