When we first got to know Dr. O'Malley, he harbored a secret crush on Meredith, with whom he shares a house, from day one. George also has a host of other insecurities. His positive outlook on life, and the fact that he is more emotional than most men, often lead to conflict with other doctors.

George doesn't fit in with his own family, either. A Thanksgiving hunting trip resulted in a George unloading a lot of emotional baggage during a conversation with his blue-collar dad and brothers (one of whom later shot the dad, forcing George to operate).

A friend and confidant of Izzie, George won praise among the entire hospital staff for saving a man's life in an elevator during a power failure. With Dr. Burke talking him through it, George stopped the bleeding in a patient's heart single-handedly after Alex choked under pressure.

After great inner strife, he admitted his feelings for Meredith and slept with her in a moment of peak vulnerability for both. After some disastrous fallout, he moved out of her house and onto Dr. Burke's sofa. He remained there until Season Two came to a close - and he found a spot in bed next to his girlfriend, Callie Torres.

In the hospital basement.

Season Three was a tough one on George O'Malley. His father had a heart surgery, then succumbed to cancer. He and Callie broke up, then married in an impromptu Las Vegas ceremony. Then he drunkenly slept with his best friend, Izzie, and has doubted his future with Callie ever since. No one knows where the carousel that is George's personal life will stop, but one thing is for sure - it's a bumpy ride.

George O'Malley Quotes

CRISTINA: "There's a club. The Dead Dads Club. And you can't be in it until you're in it. You can try to understand, you can sympathize. But until you feel that loss... My dad died when I was nine. George, I'm really sorry you had to join the club."
GEORGE: "I... I don't know how to exist in a world where my dad doesn't."
CRISTINA: "Yeah, that never really changes."

Cristina: I have five rules. Memorize them. Rule number one, don't bother sucking up. I already hate you, that's not gonna change.
Izzie: Traumas protocol, phone lists, pagers. The nurses will page you, you answer every page at a run. A RUN! That's rule number two... You're supposed to follow me!
Alex: The first shift starts now and lasts 36 hours. You're grunts, nobodies, the bottom of the surgical food chain. You run labs, write orders, work every second night until you drop. And you don't complain.
Meredith: On call rooms. Sleep when you can, where you can. You know, but not with anybody. Not attendings, especially not attendings. Sleeping with attendings, not a good idea. Where was I?
George: Er, rule number three. If you're sleeping, do not wake you unless the patient is actually dying.
Cristina: The dying patient better not be dead when I get there, because not only will you have killed someone, you will have woken me for no good reason. Are we clear? Yes?
Lexie: That was four rules. You said five.
Cristina: Rule number five. When I move, you move... Go!

Grey's Anatomy Quotes

Arizona: Oh my God! I mean, I understand why you're into her. She's hot. Wait, she likes you?
Nathan: What? I mean, I'm going to try not to be offended at that.
Arizona: No, no, no. It's just that Derek was--Derek was epic for her. They were the great love story. I mean, that girl's heart beat for Derek Shepherd. It just...it never occurred to me that she would ever be with anyone else. He was perfect. He was everything. That man turned her world. It...I spooked you. Don't be spooked.

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."