Derek Shepherd is a renowned brain surgeon who we are led to believe moved to Seattle from New York a little bit before the series debuted. He and his intern, Meredith Grey, met and slept together during the Pilot, before they even knew each other's identity, with their romance blossoming soon after.

Derek is married to Dr. Addison Montgomery Shepherd, who he left in New York after finding her in bed with his best friend Mark Sloan, a plastic surgeon. Addison joining the staff at Seattle Grace during Season Two resulted in constant conflict for Derek as he struggles to repair his marriage and deal with his feelings for Ms. Grey. Ultimately, he goes for his true love.

Dr. Shepherd was nicknamed "McDreamy" by the female interns at Seattle Grace. The man has some amazing hair. He and Dr. Preston Burke (while he was around) were among the hospital's top surgeons and there has been occasional friction other which one the chief, Dr. Richard Webber, would name as his successor.

Derek was named Chief of Surgery by Richard at the end of Season Three, but he did not accept. He and Addison got a divorce after he rekindled his love for Mer, but he has expressed doubts over that relationship's chances of lasting, as well. As he put it, he doesn't know if he can keep breathing for her.

We'll see what Season Four holds for these two.

Derek Shepherd Quotes

Lexie: [narrating] Grief may be a thing we all have in common, but it looks different on everyone.
Mark: It isn't just death we have to grieve. It's life. It's loss. It's change.
Alex: And when we wonder why it has to suck so much sometimes, has to hurt so bad. The thing we gotta try to remember is that it can turn on a dime.
Izzie: That's how you stay alive. When it hurts so much you can't breathe, that's how you survive.
Derek: By remembering that one day, somehow, impossibly, you won't feel this way. It won't hurt this much.
Bailey: Grief comes in its own time for everyone, in its own way.
Owen: So the best we can do, the best anyone can do, is try for honesty.
Meredith: The really crappy thing, the very worst part of grief is that you can't control it.
Arizona: The best we can do is try to let ourselves feel it when it comes.
Callie: And let it go when we can.
Meredith: The very worst part is that the minute you think you're past it, it starts all over again.
Cristina: And always, every time, it takes your breath away.
Meredith: There are five stages of grief. They look different on all of us, but there are always five.
Alex: Denial.
Derek: Anger.
Bailey: Bargaining.
Lexie: Depression.
Richard: Acceptance.

DEREK: "Come on, have a drink."
MEREDITH: "I can't have a drink, I'm celibate."
JOE: "You mean sober? She means sober."
MEREDITH: "No, I mean celibate. I'm practicing celibacy. Drinking does not go well with celibacy because it makes everything and everyone seem kind of porn-y. Then my head gets all cloudy and the next thing you know I'm naked. My point is that I'm celibate, and knitting is good for surgical dexterity, so I'm making a sweater."
DEREK: "You? Celibate? I don't buy it."
MEREDITH: "No more men."
ADDISON: "No more men? Really? You? I'm just asking, because we're friends."
Meredith: Every guy I meet turns out to be married.
DEREK: "Oh... ouch."
MEREDITH: "Or Mark."
ADDISON: [walks away] "Okay, I'm going to sit over there now."
MEREDITH: "Sorry. Or, remember the horrible thing I did? Remember George?"
DEREK: "You're making a sweater."
MEREDITH: "I'm making a sweater."

Grey's Anatomy Quotes

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.


If I did my job well, it's not because people listened to me. It's because they believed in me. Believed that I knew them well enough and believed in them enough to tell them how and when to use their brilliance.