Derek Shepherd is a renowned brain surgeon who we are led to believe moved to Seattle from New York a little bit before the series debuted. He and his intern, Meredith Grey, met and slept together during the Pilot, before they even knew each other's identity, with their romance blossoming soon after.

Derek is married to Dr. Addison Montgomery Shepherd, who he left in New York after finding her in bed with his best friend Mark Sloan, a plastic surgeon. Addison joining the staff at Seattle Grace during Season Two resulted in constant conflict for Derek as he struggles to repair his marriage and deal with his feelings for Ms. Grey. Ultimately, he goes for his true love.

Dr. Shepherd was nicknamed "McDreamy" by the female interns at Seattle Grace. The man has some amazing hair. He and Dr. Preston Burke (while he was around) were among the hospital's top surgeons and there has been occasional friction other which one the chief, Dr. Richard Webber, would name as his successor.

Derek was named Chief of Surgery by Richard at the end of Season Three, but he did not accept. He and Addison got a divorce after he rekindled his love for Mer, but he has expressed doubts over that relationship's chances of lasting, as well. As he put it, he doesn't know if he can keep breathing for her.

We'll see what Season Four holds for these two.

Derek Shepherd Quotes

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."

Derek: I am calling post-it, Zola, Bailey, the tumors on the wall, ferryboat scrub caps. I thought D.C. was everything. I was wrong. You... you're everything. I love you and I'm not going to stop loving you. I can't live without you. I don't want to live without you, and I'm going to do everything in my power to prove it.
Meredith: I can live without you, but I don't want to. I don't ever want to.

Grey's Anatomy Quotes

[narrating] "At the end of the day, when it comes down to it, all we really want is to be close to somebody. So this thing where we all keep our distance and pretend not to care about each other, it's usually a load of bull. So we pick and choose who we want to remain close to, and once we've chosen those people, we tend to stick close by. No matter how much we hurt them. The people that are still with you at the end of the day, those are the ones worth keeping. And sure, sometimes close can be too close. But sometimes, that invasion of personal space, it can be exactly what you need."

MEREDITH

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)