Agnes Skinner is Principal Seymor Skinner's very controlling elderly mother.  Agnes was actually revealed to have adopted Seymour during "The Principal and the Pauper."  Agnes also often serves as a friend of Marge in many adventures.

Agnes Skinner Quotes

Principle Skinner: Oh, licking envelopes can be fun! All you have to do is make a game of it.
Bart: What kind of game?
Principle Skinner: Well, for example, you could see how many you could lick in an hour, then try to break that record.
Bart: Sounds like a pretty crappy game to me.
Principle Skinner: Yes, well... Get started.

I was in love with a soldier boy on leave from Korea. It was a fifties style of romance, five minutes of sex and a lifetime of regret. He went back to his war and I went back to my dream of pole vaulting in the Helsinki Olympics. But there was a bump in the road, a bump named Seymore.

Agnes [in flashback]
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The Simpsons Quotes

You know, you remind me of a poem I can't remember, and a song that may never have existed, and a place I'm not sure I've ever been to.

Grampa

Dearest Edna, I must leave you. Why, I cannot say. Where, you cannot know. How I will get there, I haven't decided yet. But one thing I can tell you, any time I hear the wind blow it will whisper the name Edna. And so let us part with a love that will echo through the ages. ---Woodrow

"Woodrow"