The Big Bang Theory returns with new episodes on September 22 and it's not hard to guess what the main topic will be: Penny and Raj sleeping together on the May finale. Just consider the title of the premiere:

The Skank Reflex Analysis.

How will the gang react? We can't say for sure, but Kaley Cuoco told us at Comic Con she hopes Penny and Leonard find their way to each other this season. That journey gets underway in less than a month, and we've posted a handful of photos below from the fifth season opener:

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.