Before the start of the season, we teased the darkness coming to Private Practice, a story line that promised a tragedy unlike any we've seen before - and this show has seen plenty.

Well, we can now confirm, thanks to EW, that the story in question involves a major female character. Which one do you think it is, and what tragedy could await them this season?

Last week's season premiere, "Take Two," set a bunch of developments into motion, story arcs that could take any number of shocking twists. Share your predictions with us below.

Charlotte, Violet, Addison and Naomi. One of them (or Amelia) will experience tragedy.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.