Grey's Anatomy Spoilers: Trouble For Lexie and Mark

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Is trouble on the horizon for Mark and Lexie on Grey's Anatomy? You knew there had to be. Here's what executive producer Krista Vernoff tells TV Guide about that couple ...

Q: Do you have any Mark/Lexie scoop for Season 6 of Grey's Anatomy? Love them!

A: I know you won't believe it, but they're going to have problems. "They've got some obstacles for sure, but some of our more emotional moments have come from them," Grey's Anatomy executive producer Krista Vernoff reports.

That doesn't mean the coupling won't survive, however.

"We've done a lot of stories about people coming together, and now we have an opportunity to tell stories about people who are together," Vernoff says.

Now that's something we doubt people can argue with.

Sending a Signal

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."