Jessica Capshaw Previews "Heavy" Grey's Anatomy Premiere

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We hope you've got a box of tissues handy, or perhaps two, because you can expect to use them when Grey's Anatomy returns for its sixth season on Thursday, September 24.

Jessica Capshaw, the newest series regular (Dr. Arizona Robbins), teases the aftermath of George's departure and how things will be different on the set without T.R. Knight.

"Heavy" is the best way to describe this season, as compared to Season 5.

Also, with Amy Brenneman's comment on the drama at Grey's Anatomy, Jessica reveals how she deals with 17-hour workdays (ahem, Katherine Heigl), since she also has a child.

Most importantly, the 33-year-old actress spills on just how Callie Torres' (Sara Ramirez) and Arizona Robbins' budding relationship is going to progress in this coming season.

Check out the E! News video below to get the details on why the Season Six premiere will be the best yet, and then hit the comments below to share your impressions ...

[video url="" title="Jessica Capshaw Interview"][/video]

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)