Jessica Capshaw Previews "Heavy" Grey's Anatomy Premiere

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We hope you've got a box of tissues handy, or perhaps two, because you can expect to use them when Grey's Anatomy returns for its sixth season on Thursday, September 24.

Jessica Capshaw, the newest series regular (Dr. Arizona Robbins), teases the aftermath of George's departure and how things will be different on the set without T.R. Knight.

"Heavy" is the best way to describe this season, as compared to Season 5.

Also, with Amy Brenneman's comment on the drama at Grey's Anatomy, Jessica reveals how she deals with 17-hour workdays (ahem, Katherine Heigl), since she also has a child.

Most importantly, the 33-year-old actress spills on just how Callie Torres' (Sara Ramirez) and Arizona Robbins' budding relationship is going to progress in this coming season.

Check out the E! News video below to get the details on why the Season Six premiere will be the best yet, and then hit the comments below to share your impressions ...

[video url="http://www.tvfanatic.com/videos/jessica-capshaw-interview/" title="Jessica Capshaw Interview"][/video]

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith

Oh, screw beautiful. I'm brilliant. If you want to appease me, compliment my brain.

Cristina