George Clooney and Julianna Margulies are coming back to ER as part of the show's series finale.

Noah Wyle spoke to Us Weekly about these significant returns.

"There were interesting conversations to try and figure out where everyone was and how they felt about coming back and doing the final few episodes," Wyle said. "I think ultimately everyone is really excited and eager to have a sense of closure to what's been the most defining jobs of all of our lives."

As for his own return, Wyle detailed the events that lead to his reprisal of Dr. John Carter. He'll mostly be shooting scenes with former mentor Peter Benton (Eriq La Salle).

"I'm coming back from having spent five years running a refugee camp in Darfur, and I've got a significant and serious health issue that forces me to seek treatment at the hospital where he is currently employed," he told Us of his character. "So we re-enter into each others lives again."

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.