Grey's Anatomy cast member Eric Dane has taken a co-starring role alongside Owen Wilson, Jennifer Aniston and Alan Arkin in Marley & Me.

The feature film - the first for Dane since X-Men United - is an adaptation of John Grogan's bestselling memoir. David Franklin is directing.

Mr. and Mrs. Eric Dane (also known as Rebecca Gayheart).

Owen Wilson plays the ambitious reporter who moves with his wife (Aniston) to Miami for a newspaper job. Eric Dane will play the journalist's best friend, who suggests that the reporter adopt a puppy as a substitute for the children his wife wants to have.

Marley, of course, is an adorable Lab puppy but an incorrigible handful.

We're looking forward to Dane's big-screen return in Marley & Me.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.