Are Alex-Izzie, George-Callie Reunions in Store?

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Drs. Karev and Stevens heated up Grey's Anatomy in Season 2, but as we know, it didn't work out. Since then, they've become good friends... but is that it?

At the SAG Awards Monday night, Justin Chambers (Alex) weighed in on a possible Alex-Izzie reunion on Grey's Anatomy, while his Grey's co-star, Sara Ramirez (Callie) hints that there still may be hope for Callie and George.

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Married Couple

Would you like to see either or both of these couples back together?

Check out TV Guide reporter Michael Ausiello's SAG video to learn more and to watch his interviews with our favorite stars and others in the TV world.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.


Ok maybe I've too much time on my hands but here's a theory. I think Rose is Derek's 'near death experience'. He'll come to realise that he cannot live happily without mer. Just like mer thought she'd be better of dead when she was in heaven or wherever and derek was the reason she came back. I think there's a reason meredith never told derek this. Maybe i'm crazy.


I want George and Izzie to be back together, I adore them, boo to George and Callie and Alex and Izzie and boo to Shonda.


A million times no to a reunion between both couples, I hate both of them, and George and Izzie are soulmates and belong together. Not sure how anyone cannot see that.


I use to adore the whole show, but since the last end of season 3, I realized I was watching for one thing and one thing only: george and Izzie. With them over and the show revisiting the horrid couples of Alex and Izzie and George and Callie, I will be leaving the show without one look back. george and Izzie were the best thing this show ever done but they were too stupid to realize it.


There was a point when the audience was willing to forgive. We watched Season Three even though it was tough. I couldn't wait for season four. We waited and waited and waited. Now we're done. They crossed a line and it's too far gone now. Grey's used to be original now it's just plain stupid. I don't care if Derek marries Rose and Meredith drinks herself into oblivion. I just don't care. If you told me about Rose in the season premiere i would have cried. Now i just don't bloomin care. And i think that's the bottom line. Shonda and Co wants us to care about the Rose kiss and the dumping and the asking out. We don't. We would have a year ago. This isn't good TY.


I hate Alex and Izzie, if they get back together, I will have to shoot myself or puke my entire stomach out, they are gross and have no chemistry. george and Callie are ok I guess, but do not have much chemistry. George and Izzie have it all: great chemistry, great flirtatious scenes, romantic chemistry, sexual chemistry (that kiss was SO hot), friendship, comedic banter, an amazing emotional connection and true love (the way they bring each other such joy just being near each other makes me feel all warm and fuzy). So yes to Gizzie, no to g and C and A and I.


i know, i dont want to be pessimistic but i think at some point between the last episodes of season 3 and all we've watced from season 4, the show moved to a point beyond saving. we've seen that happening too many times, a show that starts out as a big hit and then just falls apart, probably because the writers feel they have to shock us and use soap-opera's techniques to keep their audience (near death experiences, the "other" woman etc), which has always proved wrong


Yeah i don't think this show can be saved. It was a must see show. I think the damage is done. Even if Derek gets down on his knees and pledges his undying love to Meredith and dumps Rose. People are past caring now. The Writer's Strike will help people get over it. Seriously what will drive people to watch Season Five. Derek and Rose. no thanks


I am fine with Alex and Izzie getting together, even though I am a hardcore George and Izzie shipper, because I like anyone with Izzie. But I despise George and Callie, they obviously weren't meant to be! And I think both of them could do better. I miss the old seasons =/


season 3 episode 1. does anybody remember this line "when i had a choice to make i chose wrong". yeah, derek said that. his behavior is totally inconsistent with his words. meredith's as well but i guess all i can ask is that people try to understand that ellis died, her father who just came back into her life slaps her and blames her for the death of the closest thing to a mother meredith ever had. not to mention she did almost die (twice). she had a rough year. her best friend was ditched at the altar and with those two, meredith said "we need this. we need you to get your happy ending". WE not YOU. plus i agree with her...i would have serious trust issues with a man who was married and didn't tell me.

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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.