Up for best drama series, besides Grey's Anatomy, are Boston Legal, Heroes, House and The Sopranos, which ended its run with 15 nominations, including two for James Gandolfini and Edie Falco.
In the race for Outstanding Comedy Series, the nominees are Entourage, The Office, 30 Rock, Two and a Half Men and Ugly Betty, which followed The Sopranos in total nominations with 11.
The top nominee is HBO's TV movie Bury My Heart at Wounded Knee, with 17. Surprises included Lost getting shut out for outstanding drama, and critically acclaimed freshman drama Friday Night Lights being blanked from several acting categories.
The Drama Nominees ...
The other contenders for leading male actor in a drama series are Hugh Laurie in House, Denis Leary in Rescue Me, James Spader in Boston Legal and Kiefer Sutherland in 24.
Lead actresses in a drama, in addition to Falco, are Patricia Arquette (Medium), Minnie Driver (The Riches), Sally Field (Brothers and Sisters), Mariska Hargitay (Law & Order: Special Victims Unit) and Kyra Sedgwick (The Closer).
The best supporting actress for drama series include a trio of Grey's Anatomy stars - Sandra Oh, Katherine Heigl and Chandra Wilson. Also up for the award are Rachel Griffiths (Brothers & Sisters), Aida Turturro and Lorraine Bracco (The Sopranos).
For best supporting actor in a drama, T.R. Knight will go up against William Shatner (Boston Legal), Masi Oka (Heroes), Terry O'Quinn and Michael Emerson (Lost).
As for the Comedies ...
Lead actress nominees are Tina Fey (30 Rock), America Ferrara (Ugly Betty), Julia Louis-Dreyfus (The New Adventures of Old Christine), Felicity Huffman (Desperate Housewives) and Mary-Louise Parker for Weeds.
Among the males, it's Alec Baldwin (30 Rock), Steve Carell (The Office), Ricky Gervais (Extras), Tony Shalhoub (Monk) and Charlie Sheen (Two and Half Men).
The Emmys will be broadcast live on FOX Sunday, September 16.