On Wednesday, Patrick Dempsey, a.k.a. Derek Shepherd, checked out of Seattle Grace temporarily to film his forthcoming romantic comedy, Made of Honor, on a Los Angeles movie set.

Made of Honor tells the story of a guy in love with an engaged woman tries to win her over after she asks him to be her maid of honor.

Patrick Dempsey, who will drive the pace car at this month's Indianapolis 500, strolled between his trailer and the film set with a cup of coffee and shot scenes with his co-stars (a couple of lucky females).

Click to enlarge these pictures of Patrick on the set. Looks like Dempsey sure is McDreamy both on and off the Grey's Anatomy set - not that we're new here. He was named one of the world's most beautiful, after all.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.