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Rob Lowe: Almost Dr. McDreamy

by at . Comments

We knew that Isaiah Washington originally tried out for the role of Dr. Derek Shepherd during the casting of Grey's Anatomy before being offered the role of Dr. Preston Burke. But it turns out he's not the only well-known (and handsome) actor to have been considered for the McDreamy role that went to Patrick Dempsey and revitalized his career.

Former "Brat Pack" member and West Wing star Rob Lowe is said to have been in serious talks about playing Dr. Shepherd - and the actor himself withdrew from consideration. In a recent interview, he said it was the first time in his career that he chose wrong.

Crazy stuff. The only wrong choice Patrick made (in his own words) was Addison over Meredith in Season 2, but that isn't really the same.

  • Rob Lowe as Sam Seaborn
  • Patrick Dempsey as Dr. Derek Shepherd

There could never be another Derek, which Dempsey portrays to perfection and displays wonderful chemistry with Ellen Pompeo. But you have to admit that Rob Lowe has certain McDreamy qualities. He recently joined the cast of ABC's Brothers & Sisters, however, so you can catch him there!

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Thank GOD Rob Lowe backed out! I can not even imagine anyone but our dear Patrick playing the roll of Derrick. The way he looks at Meredith.... it just wouldn't be the same.

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I am so glad Patrick got the part. I don't think Rob Lowe would have developed the character as good as Patrick did. The chemistry he has with Ellen is very rare.

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Wow -- I just can't picture Rob Lowe as Derek. Patrick Dempsey just owns that character. I just don't think it would have been the same if Rob Lowe had been cast.

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"The only wrong choice Patrick made (in his own words) was Addison over Meredith in Season 2, but that isn't really the same." I love Patrick.

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Patrick is perfect and his chemistry with Ellen is amazing!

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RL may have chose wrong but we got the right man--no one but Patrick but could be our McDreamy!

Grey's Anatomy Quotes

Vulnerability isn't the opposite of strength. It's a necessary part. You have to force yourselves to open up, to expose ourselves, to offer everything we have and just pray that it's good enough. Otherwise, we'll never succeed.

Meredith

Our lives are built on our mistakes as much as our successes.

Ellis
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