Rob Lowe: Almost Dr. McDreamy

at . Comments

We knew that Isaiah Washington originally tried out for the role of Dr. Derek Shepherd during the casting of Grey's Anatomy before being offered the role of Dr. Preston Burke. But it turns out he's not the only well-known (and handsome) actor to have been considered for the McDreamy role that went to Patrick Dempsey and revitalized his career.

Former "Brat Pack" member and West Wing star Rob Lowe is said to have been in serious talks about playing Dr. Shepherd - and the actor himself withdrew from consideration. In a recent interview, he said it was the first time in his career that he chose wrong.

Crazy stuff. The only wrong choice Patrick made (in his own words) was Addison over Meredith in Season 2, but that isn't really the same.

Rob Lowe as Sam Seaborn
Patrick Dempsey as Dr. Derek Shepherd

There could never be another Derek, which Dempsey portrays to perfection and displays wonderful chemistry with Ellen Pompeo. But you have to admit that Rob Lowe has certain McDreamy qualities. He recently joined the cast of ABC's Brothers & Sisters, however, so you can catch him there!

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

Avatar

Thank GOD Rob Lowe backed out! I can not even imagine anyone but our dear Patrick playing the roll of Derrick. The way he looks at Meredith.... it just wouldn't be the same.

Avatar

I am so glad Patrick got the part. I don't think Rob Lowe would have developed the character as good as Patrick did. The chemistry he has with Ellen is very rare.

Avatar

Wow -- I just can't picture Rob Lowe as Derek. Patrick Dempsey just owns that character. I just don't think it would have been the same if Rob Lowe had been cast.

Avatar

"The only wrong choice Patrick made (in his own words) was Addison over Meredith in Season 2, but that isn't really the same." I love Patrick.

Avatar

Patrick is perfect and his chemistry with Ellen is amazing!

Avatar

RL may have chose wrong but we got the right man--no one but Patrick but could be our McDreamy!

Tags:

Grey's Anatomy Quotes

Amelia: I think I'm falling in love with Owen Hunt, and I'm really afraid that it's gonna destroy me.
Derek: It wouldn't be love if it didn't.

I want to marry you. I want to have kids with you. I want to build us a house. I want to settle down and grow old with you. I want to die when I'm 110 years old, in your arms. I don't want 48 uninterrupted hours. I want a lifetime. Mmm. Do you see what happens? I say things like that and you fight the urge to run in the opposite direction. It's okay, I understand. I didn't, but now I do, I do. You're just getting started and I've been doing this for a long time now. Deep down, you're still an intern, and you're not ready.

Derek